Placental methylome reveals a 22q13.33 brain regulatory gene locus associated with autism.

ABSTRACT:

Background

Autism spectrum disorder (ASD) involves complex genetics interacting with the perinatal environment, complicating the discovery of common genetic risk. The epigenetic layer of DNA methylation shows dynamic developmental changes and molecular memory of in utero experiences, particularly in placenta, a fetal tissue discarded at birth. However, current array-based methods to identify novel ASD risk genes lack coverage of the most structurally and epigenetically variable regions of the human genome.

Results

We use whole genome bisulfite sequencing in placenta samples from prospective ASD studies to discover a previously uncharacterized ASD risk gene, LOC105373085, renamed NHIP. Out of 134 differentially methylated regions associated with ASD in placental samples, a cl

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC8848662 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature