Asprosin induces vascular endothelial-to-mesenchymal transition in diabetic lower extremity peripheral artery disease.

ABSTRACT:

Background

Altered adipokine secretion in dysfunctional adipose tissue facilitates the development of atherosclerotic diseases including lower extremity peripheral artery disease (PAD). Asprosin is a recently identified adipokine and displays potent regulatory role in metabolism, but the relationship between asprosin and lower extremity PAD remains uninvestigated.

Methods

33 type 2 diabetes mellitus (T2DM) patients (DM), 51 T2DM patients with PAD (DM + PAD) and 30 healthy normal control (NC) volunteers were recruited and the blood samples were collected for detecting the circulatory asprosin level and metabolomic screening. RNA sequencing was performed using the aorta tissues from the type 2 diabetic db/db mice and human umbilical vein endothelial cells (HUVECs) were treated

SUBMITTER: You M 

PROVIDER: S-EPMC8848671 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature