Assessing the role of blood pressure in amyotrophic lateral sclerosis: a Mendelian randomization study.

ABSTRACT:

Background

Observational studies have suggested a close but controversial relationship between blood pressure (BP) and amyotrophic lateral sclerosis (ALS). It remains unclear whether this association is causal. The authors employed a bidirectional two-sample Mendelian randomization (MR) approach to evaluate the causal relationship between BP and ALS. Genetic proxies for systolic blood pressure (SBP), diastolic blood pressure (DBP), antihypertensive drugs (AHDs), ALS, and their corresponding genome-wide association study (GWAS) summary datasets were obtained from the most recent studies with the largest sample sizes. The inverse variance weighted (IVW) method was adopted as the main approach to examine the effect of BP on ALS and four other MR methods were used for sensitivity analy

SUBMITTER: Xia K 

PROVIDER: S-EPMC8848798 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature