Caspase-1 variant influencing CSF tau and FDG PET levels in non-demented elders from the ADNI cohort.

ABSTRACT:

Background

Genetic variations in the inflammatory Caspase-1 gene have been shown associated with cognitive function in elderly individuals and in predisposition to Alzheimer's disease (AD), but its detailed mechanism before the typical AD onset was still unclear. Our current study evaluated the impact of Caspase-1 common variant rs554344 on the pathological processes of brain amyloidosis, tauopathy, and neurodegeneration.

Methods

Data used in our study were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. We examined the relationship between Caspase-1 rs554344 allele carrier status with AD-related cerebrospinal fluid (CSF), PET, and MRI measures at baseline by using a multiple linear regression model. We also analyzed the longitudinal effects of t

SUBMITTER: Liu Y 

PROVIDER: S-EPMC8848902 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature