A comprehensive profile of chemokines in the peripheral blood and vascular tissue of patients with Takayasu arteritis.

ABSTRACT:

Background

Takayasu arteritis (TAK) is a chronic granulomatous large vessel vasculitis with multiple immune cells involved. Chemokines play critical roles in recruitment and activation of immune cells. This study aimed to investigate chemokine profile in the peripheral blood and vascular tissue of patients with TAK.

Methods

A total of 58 patients with TAK and 53 healthy controls were enrolled. Chemokine array assay was performed in five patients with TAK and three controls. Chemokines with higher levels were preliminarily validated in 20 patients and controls. The validated chemokines were further confirmed in another group of samples with 25 patients and 25 controls. Their expression and distribution were also examined in vascular tissue from 8 patients and 5 controls. Corr

SUBMITTER: Kong X 

PROVIDER: S-EPMC8848964 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature