Genetic mutation profiles and immune microenvironment analysis of pulmonary enteric adenocarcinoma.

ABSTRACT:

Background

Pulmonary enteric adenocarcinoma (PEAC) has distinctive clinical outcomes, radiographic, pathological and molecular characteristics. The prognosis of patients with PEAC was poor. However, molecular profiles and therapeutic biomarkers of PEAC remain elusive.

Methods

In the present study, the hospitalized patients with PEAC admitted to Tongji Hospital in Wuhan from January 1, 2014 to November 20, 2020 were retrospectively enrolled and followed until December 10, 2020. Comprehensive genomic profiling of tumor tissue from the PEAC patients were performed and compared with lung adenocarcinoma, colorectal cancer and metastatic colorectal carcinoma. Tumor immune microenvironment analysis were evaluated.

Results

There were 10 patients with PEAC enrolled. 70% of pat

SUBMITTER: Xie M 

PROVIDER: S-EPMC8849039 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature