Spreading Advantages of Coresident Plasmids bla_CTX-M-Bearing IncFII and mcr-1-Bearing IncI2 in Escherichia coli.

ABSTRACT: Two diverse conjugative plasmids can interact within bacterial cells. However, to the best of our knowledge, the interaction between bla_CTX-M-bearing IncFII plasmid and mcr-1-carrying IncI2 plasmid colocated on the same bacterial host has not been reported. This study was initiated to explore the interaction and to analyze the reasons that these two plasmids are often coresident in multidrug-resistant Escherichia coli. To assess the interactions on plasmid stabilities, fitness costs, and transfer rates, we constructed two groups of isogenic derivatives, C600_FII, C600_I2, and C600_FII+I2 of E. coli C600 and J53_FII, J53_I2, and J53_FII+I2 of E. coli J53, respectively. We found that carriage of FII and I2 p

SUBMITTER: He K 

PROVIDER: S-EPMC8849077 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature