Systemic inflammation and metabolic disturbances underlie inpatient mortality among ill children with severe malnutrition.

ABSTRACT: Children admitted to hospital with an acute illness and concurrent severe malnutrition [complicated severe malnutrition (CSM)] have a high risk of dying. The biological processes underlying their mortality are poorly understood. In this case-control study nested within a multicenter randomized controlled trial among children with CSM in Kenya and Malawi, we found that blood metabolomic and proteomic profiles robustly differentiated children who died (n = 92) from those who survived (n = 92). Fatalities were characterized by increased energetic substrates (tricarboxylic acid cycle metabolites), microbial metabolites (e.g., propionate and isobutyrate), acute phase proteins (e.g., calprotectin and C-reactive protein), and inflammatory markers (e.g., interleukin-8 and tumor necro

SUBMITTER: Wen B 

PROVIDER: S-EPMC8849276 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature