Chronic paternal morphine exposure increases sensitivity to morphine-derived pain relief in male progeny.

ABSTRACT: Parental history of opioid exposure is seldom considered when prescribing opioids for pain relief. To explore whether parental opioid exposure may affect sensitivity to morphine in offspring, we developed a "rat pain scale" with high-speed imaging, machine learning, and mathematical modeling in a multigenerational model of paternal morphine self-administration. We find that the most commonly used tool to measure mechanical sensitivity in rodents, the von Frey hair, is not painful in rats during baseline conditions. We also find that male progeny of morphine-treated sires had no baseline changes in mechanical pain sensitivity but were more sensitive to the pain-relieving effects of morphine. Using RNA sequencing across pain-relevant brain regions, we identify gene expression changes within

SUBMITTER: Toussaint AB 

PROVIDER: S-EPMC8849295 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature