A Preliminary Study for an Intraoperative 3D Bioprinting Treatment of Severe Burn Injuries.

ABSTRACT: Intraoperative three-dimensional fabrication of living tissues could be the next biomedical revolution in patient treatment.

Approach

We developed a surgery-ready robotic three-dimensional bioprinter and demonstrated that a bioprinting procedure using medical grade hydrogel could be performed using a 6-axis robotic arm in vivo for treating burn injuries.

Results

We conducted a pilot swine animal study on a deep third-degree severe burn model. We observed that the use of cell-laden bioink as treatment substantially affects skin regeneration, producing in situ fibroblast growth factor and vascular endothelial growth factor, necessary for tissue regeneration and re-epidermalization of the wound.

Conclusions

We described an animal study of intraoperative three-dimensional

SUBMITTER: Albouy M 

PROVIDER: S-EPMC8849420 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature