Familial Hypercholesterolemia Prevalence Among Ethnicities-Systematic Review and Meta-Analysis.

ABSTRACT: Background: Heterozygous familial hypercholesterolemia (FH) is a common genetic disorder leading to premature cardiovascular disease and death as a result of lifelong high plasma low-density lipoprotein cholesterol levels, if not treated early in life. The prevalence of FH varies between countries because of founder effects, use of different diagnostic criteria, and screening strategies. However, little is known about differences in FH prevalence according to ethnicity. We aimed to investigate the ethnic distribution of FH in diverse populations and estimate the prevalence of FH according to ethnicity. Methods: We performed a systematic review and meta-analysis, searching PubMed and Web of Science for studies presenting data on the prevalence of heterozygous FH among differen

SUBMITTER: Toft-Nielsen F 

PROVIDER: S-EPMC8850281 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature