A Spontaneous Model of Experimental Autoimmune Encephalomyelitis Provides Evidence of MOG-Specific B Cell Recruitment and Clonal Expansion.

ABSTRACT: The key role of B cells in the pathophysiology of multiple sclerosis (MS) is supported by the presence of oligoclonal bands in the cerebrospinal fluid, by the association of meningeal ectopic B cell follicles with demyelination, axonal loss and reduction of astrocytes, as well as by the high efficacy of B lymphocyte depletion in controlling inflammatory parameters of MS. Here, we use a spontaneous model of experimental autoimmune encephalomyelitis (EAE) to study the clonality of the B cell response targeting myelin oligodendrocyte glycoprotein (MOG). In particular, 94% of SJL/j mice expressing an I-A^s: MOG_92-106 specific transgenic T cell receptor (TCR¹⁶⁴⁰) spontaneously develop a chronic paralytic EAE between the age of 60-500 days. The immune response is

SUBMITTER: Salvador F 

PROVIDER: S-EPMC8850296 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature