Striatal D₁ Dopamine Neuronal Population Dynamics in a Rat Model of Levodopa-Induced Dyskinesia.

ABSTRACT:

Background

The pathophysiology of levodopa-induced dyskinesia (LID) in Parkinson's disease (PD) is not well understood. Experimental data from numerous investigations support the idea that aberrant activity of D₁ dopamine receptor-positive medium spiny neurons in the striatal direct pathway is associated with LID. However, a direct link between the real-time activity of these striatal neurons and dyskinetic symptoms remains to be established.

Methods

We examined the effect of acute levodopa treatment on striatal c-Fos expression in LID using D₁-Cre PD rats with dyskinetic symptoms induced by chronic levodopa administration. We studied the real-time dynamics of striatal D₁ ⁺ neurons during dyskinetic behavior using GCaMP₆

SUBMITTER: Gao S 

PROVIDER: S-EPMC8850470 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature