Application of 233 nm far-UVC LEDs for eradication of MRSA and MSSA and risk assessment on skin models.

ABSTRACT: A newly developed UVC LED source with an emission wavelength of 233 nm was proved on bactericidal efficacy and skin tolerability. The bactericidal efficacy was qualitatively analysed using blood agar test. Subsequently, quantitative analyses were performed on germ carrier tests using the MRSA strain DSM11822, the MSSA strain DSM799, S. epidermidis DSM1798 with various soil loads. Additionally, the compatibility of the germicidal radiation doses on excised human skin and reconstructed human epidermis was proved. Cell viability, DNA damage and production of radicals were assessed in comparison to typical UVC radiation from discharge lamps (222 nm, 254 nm) and UVB (280-380 nm) radiation for clinical assessment. At a dose of 40 mJ/cm², the 233 nm light source reduced the viable micr

SUBMITTER: Zwicker P 

PROVIDER: S-EPMC8850561 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature