Cannabidiol Inhibits Multiple Ion Channels in Rabbit Ventricular Cardiomyocytes.

ABSTRACT: Cannabidiol (CBD), a major non-psychotropic cannabinoid found in the Cannabis plant, has been shown to exert anti-nociceptive, anti-psychotic, and anti-convulsant effects and to also influence the cardiovascular system. In this study, the effects of CBD on major ion currents were investigated using the patch-clamp technique in rabbit ventricular myocytes. CBD inhibited voltage-gated Na⁺ and Ca²⁺ channels with IC₅₀ values of 5.4 and 4.8 µM, respectively. In addition, CBD, at lower concentrations, suppressed ion currents mediated by rapidly and slowly activated delayed rectifier K⁺ channels with IC₅₀ of 2.4 and 2.1 µM, respectively. CBD, up to 10 μM, did not have any significant effect on inward rectifier I _K1 and trans

SUBMITTER: Isaev D 

PROVIDER: S-EPMC8850628 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature