Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation.

ABSTRACT:

Rationale

Asthma phenotyping requires novel biomarker discovery.

Objectives

To identify plasma biomarkers associated with asthma phenotypes by application of a new proteomic panel to samples from two well-characterised cohorts of severe (SA) and mild-to-moderate (MMA) asthmatics, COPD subjects and healthy controls (HCs).

Methods

An antibody-based array targeting 177 proteins predominantly involved in pathways relevant to inflammation, lipid metabolism, signal transduction and extracellular matrix was applied to plasma from 525 asthmatics and HCs in the U-BIOPRED cohort, and 142 subjects with asthma and COPD from the validation cohort BIOAIR. Effects of oral corticosteroids (OCS) were determined by a 2-week, placebo-controlled OCS trial in BIOAIR, and confirmed by rela

SUBMITTER: Sparreman Mikus M 

PROVIDER: S-EPMC8850689 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature