Analysis of age-related left ventricular collagen remodeling in living donors: Implications in arrhythmogenesis.

ABSTRACT: Age-related fibrosis in the left ventricle (LV) has been mainly studied in animals by assessing collagen content. Using second-harmonic generation microscopy and image processing, we evaluated amount, aggregation and spatial distribution of LV collagen in young to old pigs, and middle-age and elder living donors. All collagen features increased when comparing adult and old pigs with young ones, but not when comparing adult with old pigs or middle-age with elder individuals. Remarkably, all collagen parameters strongly correlated with lipofuscin, a biological age marker, in humans. By building patient-specific models of human ventricular tissue electrophysiology, we confirmed that amount and organization of fibrosis modulated arrhythmia vulnerability, and that distribution should be account

SUBMITTER: Garcia-Mendivil L 

PROVIDER: S-EPMC8850748 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature