Octahedral Pt-MOF with Au deposition for plasmonic effect and Schottky junction enhanced hydrogenothermal therapy of rheumatoid arthritis.

ABSTRACT: Hydrogen (H₂) therapy is a novel and rapidly developing strategy utilized to treat inflammatory diseases. However, the therapeutic efficacy of H₂ is largely limited with on-target off-synovium toxic effect, nonpolarity and low solubility. Herein, an intelligent H₂ nanogenerator based upon the metal-organic framework (MOF) loaded with polydopamine and Perovskite quantum dots is constructed for the actualization of hydrogenothermal therapy. The biodegradable polydopamine with excellent photothermal conversion efficiencies is used for photothermal therapy (PTT) of rheumatoid arthritis (RA) and perovskite quantum dots (QDs) with unique photophysical properties are used as fluorescent signals for positioning Pt-MOF@Au@QDs/PDA nanoparticles. In addition, the Pt-M

SUBMITTER: Pan W 

PROVIDER: S-EPMC8850757 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature