Aquaglyceroporin Modulators as Emergent Pharmacological Molecules for Human Diseases.

ABSTRACT: Aquaglyceroporins, a sub-class of aquaporins that facilitate the diffusion of water, glycerol and other small uncharged solutes across cell membranes, have been recognized for their important role in human physiology and their involvement in multiple disorders, mostly related to disturbed energy homeostasis. Aquaglyceroporins dysfunction in a variety of pathological conditions highlighted their targeting as novel therapeutic strategies, boosting the search for potent and selective modulators with pharmacological properties. The identification of selective inhibitors with potential clinical applications has been challenging, relying on accurate assays to measure membrane glycerol permeability and validate effective functional blockers. Additionally, biologicals such as hormones and natural

SUBMITTER: Pimpao C 

PROVIDER: S-EPMC8850838 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature