Association between HOTAIR Polymorphisms and Lymphoma.

ABSTRACT:

Introduction

The long non-coding RNA, HOTAIR, involved in cancer initiation and development.

Objective

The aim of present study was to investigate the association of single nucleotide polymorphisms in the HOTAIR gene with lymphoma.

Methods

We conducted a case-control study of 156 individuals with non-Hodgkin Lymphoma (NHL), 53 individuals with Hodgkin's lymphoma (HL), and 245 unrelated healthy individuals to identify the genotype frequencies of each polymorphism. Genotyping of the SNPs (rs920778 T>C, rs1899663 G>T, rs4759314 A>G and rs12826786 C>T) was carried out using the polymerase chain reaction-restriction fragment length polymorphism.

Results and conclusion

The finding showed that rs1899663 variant of HOTAIR gene significantly decreased the risk of NHL in

SUBMITTER: Kashani S 

PROVIDER: S-EPMC8850905 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature