The role of vitamin D in prevention OF COVID-19 and its severity: an umbrella review.

ABSTRACT:

Background and aim

Vitamin D is known to modulate immune response and its deficiency was associated with respiratory distress in patients hospitalized for pneumonia. Nevertheless, numerous reviews on vitamin D in COVID-19 patients have shown conflicting results, as previously reported also for other respiratory diseases (e.g., influenza).

Methods

This umbrella review aims to assess whether low serum 25-OHD is associated with susceptibility to COVID 19, their severity, and mortality. A total of 1559 studies were excluded after the title, abstract and full-text articles screening and 9 papers were included in this review: 2 systematic reviews and 7 metanalysis.

Results

The findings of this review that summarized studies from 5 WHO regions (European Region, Region of the

SUBMITTER: Margarucci LM 

PROVIDER: S-EPMC8851027 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature