Comparison Study of Stem Cell-Derived Extracellular Vesicles for Enhanced Osteogenic Differentiation.

ABSTRACT: Stem cell-derived extracellular vesicles (EVs) have shown great promise in the field of regenerative medicine and tissue engineering. Recently, human bone marrow-derived mesenchymal stem cell (BMSC)-derived EVs have been considered for bone tissue engineering applications. In this study, we evaluated the osteogenic capability of placental stem cell (PSC)-derived EVs and compared them to the well-characterized BMSC-derived EVs. EVs were extracted from three designated time points (0, 7, and 21 days) after osteogenic differentiation. The results showed that the PSC-derived EVs had much higher protein and lipid concentrations than EVs derived from BMSCs. The extracted EVs were characterized by observing their morphology and size distribution before utilizing next-generation sequencing to dete

SUBMITTER: Pishavar E 

PROVIDER: S-EPMC8851217 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature