Endothelial/Mesenchymal Stem Cell Crosstalk Within Bioprinted Cocultures.

ABSTRACT: The development of viable tissue surrogates requires a vascular network that sustains cell metabolism and tissue development. The coculture of endothelial cells (ECs) and mesenchymal stem cells (MSCs), the two key players involved in blood vessel formation, has been heralded in tissue engineering (TE) as one of the most promising approaches for scaffold vascularization. However, MSCs may exert both proangiogenic and antiangiogenic role. Furthermore, it is unclear which cell type is responsible for the upregulation of angiogenic pathways observed in EC:MSC cocultures. There is disagreement on the proangiogenic action of MSCs, as they have also been shown to negatively affect the formation of capillary networks. To address these issues, we investigated the regulation of key angiogenic pathwa

SUBMITTER: Santoro M 

PROVIDER: S-EPMC8851226 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature