EGFR Testing Patterns and Detection of EGFR Exon 20 Insertions in the United States.

ABSTRACT:

Introduction

EGFR exon 20 insertions (EGFRex20ins) are a diverse set of mutations in NSCLC that are refractory to tyrosine kinase inhibitors. We describe real-world EGFRex20ins detection patterns in patients with advanced NSCLC in the United States.

Methods

Data from 2011 to 2020 were extracted from the Flatiron Health electronic health record-derived deidentified database.

Results

Among 67,281 patients with advanced NSCLC and at least two clinic visits, 66.8% were tested for EGFR mutations, of whom 13.9% tested positive. Of these, 4.9% had EGFRex20ins. The median time from NSCLC diagnosis to the first positive EGFRex20ins test result was 23 days, including 9 days of laboratory testing time. The EGFRex20ins were reporte

SUBMITTER: Lin HM 

PROVIDER: S-EPMC8851244 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature