Association between enterovirus infection and clinical type 1 diabetes mellitus: systematic review and meta-analysis of observational studies.

ABSTRACT: Numerous animal models and epidemiological and observational studies have demonstrated that enterovirus (EV) infection could be involved in the development of clinical type 1 diabetes mellitus (T1DM), but its aetiology is not fully understood. Therefore, we reviewed the association between EV infection and clinical T1DM. We searched PubMed and Embase from inception to April 2021 and reference lists of included studies without any language restrictions in only human studies. The correlation between EV infection and clinical T1DM was calculated as the pooled odds ratio (OR) and 95% confidence intervals (CIs), analysed using random-effects models. Subgroup and sensitivity analyses were performed to evaluate the robustness of the associations. A total of 25 articles (22 case-control studies an

SUBMITTER: Yang S 

PROVIDER: S-EPMC8851353 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature