Combining Antidepressants vs Antidepressant Monotherapy for Treatment of Patients With Acute Depression: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Combining antidepressants is frequently done in the treatment of acute depression, but studies have yielded conflicting results.

Objective

To conduct a systematic review and meta-analysis assessing efficacy and tolerability of combination therapy. Combinations using presynaptic α2-autoreceptor antagonists or bupropion were investigated separately.

Data sources

MEDLINE, Embase, PsycINFO, and the Cochrane Central Register of Controlled Trials were systematically searched from each database inception through January 2020.

Study selection

Randomized clinical trials (RCTs) comparing combinations of antidepressants with antidepressant monotherapy in adult patients with acute depression were included.

Data extraction and synthesis

Following guideline

SUBMITTER: Henssler J 

PROVIDER: S-EPMC8851370 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature