Typical tumor immune microenvironment status determine prognosis in lung adenocarcinoma.

ABSTRACT:

Background

Immune cells, vital components of tumor microenvironment, regulate tumor survival and progression. Lung adenocarcinoma (LUAD), the tumor with the highest mortality rate worldwide, reconstitutes tumor immune microenvironment (TIME) to avoid immune destruction. Data have shown that TIME influences LUAD prognosis and predicts immunotherapeutic efficacy. The related information about the role of TIME's characteristics in LUAD is limited.

Methods

We performed unsupervised consensus clustering via machine-learning techniques to identify TIME clusters among 1906 patients and gathered survival data. The characteristics of TIME clusters of LUAD were visualized by multi-omics analysis, pseudo-time dynamic analysis, and enrichment analysis. TIME score model was constructed b

SUBMITTER: Ren C 

PROVIDER: S-EPMC8851380 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature