Identification of molecular subtyping system and four-gene prognostic signature with immune-related genes for uveal melanoma.

ABSTRACT: Immunotherapy is the most promising treatment for uveal melanoma patients with metastasis. Tumor microenvironment plays an essential role in tumor progression and greatly affects the efficacy of immunotherapy. This research constructed an immune-related subtyping system and discovered immune prognostic genes to further understand the immune mechanism in uveal melanoma. Immune-related genes were determined from literature. Gene expression profiles of uveal melanoma were clustered using consensus clustering based on immune-related genes. Subtypes were further divided by applying immune landscape, and weighted correlation network analysis was performed to construct immune gene modules. Univariate Cox regression analysis was conducted to generate a prognostic model. Enriched immune cells were

SUBMITTER: Xia F 

PROVIDER: S-EPMC8851532 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature