A distinct role of STING in regulating glucose homeostasis through insulin sensitivity and insulin secretion.

ABSTRACT: Insulin resistance and β-cell dysfunction are two main molecular bases yet to be further elucidated for type 2 diabetes (T2D). Accumulating evidence indicates that stimulator of interferon genes (STING) plays an important role in regulating insulin sensitivity. However, its function in β-cells remains unknown. Herein, using global STING knockout (STING^-/-) and β-cell-specific STING knockout (STING-βKO) mouse models, we revealed a distinct role of STING in the regulation of glucose homeostasis through peripheral tissues and β-cells. Specially, although STING^-/- beneficially alleviated insulin resistance and glucose intolerance induced by high-fat diet, it surprisingly impaired islet glucose-stimulated insulin secretion (GSIS). Importantly, STING is decreased in islets

SUBMITTER: Qiao J 

PROVIDER: S-EPMC8851542 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature