Self-healing codes: How stable neural populations can track continually reconfiguring neural representations.

ABSTRACT: As an adaptive system, the brain must retain a faithful representation of the world while continuously integrating new information. Recent experiments have measured population activity in cortical and hippocampal circuits over many days and found that patterns of neural activity associated with fixed behavioral variables and percepts change dramatically over time. Such "representational drift" raises the question of how malleable population codes can interact coherently with stable long-term representations that are found in other circuits and with relatively rigid topographic mappings of peripheral sensory and motor signals. We explore how known plasticity mechanisms can allow single neurons to reliably read out an evolving population code without external error feedback. We find that int

SUBMITTER: Rule ME 

PROVIDER: S-EPMC8851551 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature