Sex differences in outcomes after coronary artery bypass grafting: a pooled analysis of individual patient data.

ABSTRACT:

Aims

Data suggest that women have worse outcomes than men after coronary artery bypass grafting (CABG), but results have been inconsistent across studies. Due to the large differences in baseline characteristics between sexes, suboptimal risk adjustment due to low-quality data may be the reason for the observed differences. To overcome this limitation, we undertook a systematic review and pooled analysis of high-quality individual patient data from large CABG trials to compare the adjusted outcomes of women and men.

Methods and results

The primary outcome was a composite of all-cause mortality, myocardial infarction (MI), stroke, and repeat revascularization (major adverse cardiac and cerebrovascular events, MACCE). The secondary outcome was all-cause mortality. Multivariabl

SUBMITTER: Gaudino M 

PROVIDER: S-EPMC8851663 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature