Neutrophils produce proinflammatory or anti-inflammatory extracellular vesicles depending on the environmental conditions.

ABSTRACT: Extracellular vesicles (EVs) are important elements of intercellular communication. A plethora of different, occasionally even opposite, physiologic and pathologic effects have been attributed to these vesicles in the last decade. A direct comparison of individual observations is however hampered by the significant differences in the way of elicitation, collection, handling, and storage of the investigated vesicles. In the current work, we carried out a careful comparative study on 3, previously characterized types of EVs produced by neutrophilic granulocytes. We investigated in parallel the modulation of multiple blood-related cells and functions by medium-sized vesicles. We show that EVs released from resting neutrophils exert anti-inflammatory action by reducing production of reactive o

SUBMITTER: Kolonics F 

PROVIDER: S-EPMC8851677 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature