Antibody attributes that predict the neutralization and effector function of polyclonal responses to SARS-CoV-2.

ABSTRACT:

Background

While antibodies can provide significant protection from SARS-CoV-2 infection and disease sequelae, the specific attributes of the humoral response that contribute to immunity are incompletely defined.

Methods

We employ machine learning to relate characteristics of the polyclonal antibody response raised by natural infection to diverse antibody effector functions and neutralization potency with the goal of generating both accurate predictions of each activity based on antibody response profiles as well as insights into antibody mechanisms of action.

Results

To this end, antibody-mediated phagocytosis, cytotoxicity, complement deposition, and neutralization were accurately predicted from biophysical antibody profiles in both discovery and validation cohorts.

SUBMITTER: Natarajan H 

PROVIDER: S-EPMC8851712 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature