Differences in tumor-infiltrating lymphocyte density and prognostic factors for breast cancer by patient age.

ABSTRACT:

Background

Lymphocytes that surround cancer participate in tumor-related immune responses and are called tumor-infiltrating lymphocytes (TILs). Several recent reports suggest TILs index the tumor microenvironment and predict the therapeutic effect of chemotherapy. However, only few studies have studied the relationship between age and TILs. Aging reduces host immunity, and we predict that it may also affect TILs. Thus, we hypothesized that older breast cancer (BC) patients may have low TIL density than younger BC patients. Here, we retrospectively analyzed the differences in TILs by age and the therapeutic effects of preoperative chemotherapy (POC) in BC patients who were aged either less than 45 years or more than 60 years.

Methods

We retrospectively examined the data of 35

SUBMITTER: Takada K 

PROVIDER: S-EPMC8851811 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature