Obstructive sleep apnea and atrial fibrillation: insights from a bidirectional Mendelian randomization study.

ABSTRACT:

Background

Observational studies have suggested that obstructive sleep apnea (OSA) is in relation to atrial fibrillation (AF); however, these studies might be confounded and whether the relationship is causal remains unclear. We conducted a bidirectional Mendelian randomization (MR) study to clarify the causal inference between OSA and AF.

Methods

Genetic instruments for OSA and AF were obtained from genome-wide association studies. The fixed-effects inverse-variance weighted (IVW) method was used as the main method, supplemented by several sensitivity analyses. For replication, another AF dataset was used to validate the causal effect of OSA on AF. Furthermore, multivariable MR analyses were performed to obtain direct estimates adjusting for potential confounders.

Result

SUBMITTER: Chen L 

PROVIDER: S-EPMC8851818 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature