First-degree relationships and genotyping errors deciphered by a high-density SNP array in a Duroc × Iberian pig cross.

ABSTRACT:

Background

Two individuals with a first-degree relationship share about 50 percent of their alleles. Parent-offspring relationships cannot be homozygous for alternative alleles (genetic exclusion).

Methods

Applying the concept of genetic exclusion to HD arrays typed in animals for experimental purposes or genomic selection allows estimation of the rate of rejection of first-degree relationships as the rate at which two individuals typed for a large number of Single Nucleotide Polymorphisms (SNPs) do not share at least one allele. An Expectation-Maximization algorithm is applied to estimate parentage. In addition, genotyping errors are estimated in true parent-offspring relationships. Samples from nine candidate Duroc sires and 55 Iberian dams producing 214 Duroc × Iberian ba

SUBMITTER: Gomez-Raya L 

PROVIDER: S-EPMC8851823 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature