Effectiveness of a multi-faceted intervention to deprescribe proton pump inhibitors in primary care: protocol for a population-based, pragmatic, cluster-randomized controlled trial.

ABSTRACT:

Background

Inappropriately using proton pump inhibitors (PPI) is associated with severe adverse drug reactions and may have major consequences on healthcare costs. Deprescribing (the process by which a healthcare professional supervises the withdrawal of an inappropriate medication, to manage polypharmacy and improve outcomes) should be considered when an inappropriate PPI prescription is identified. Deprescribing interventions directed solely to prescribers have limited efficacy and are rarely targeted to patients. The aim of this trial is to assess the efficacy of a multi-faceted intervention with patients and general practitioners (GPs) to deprescribe PPI.

Methods

We will conduct a pragmatic, cluster-randomized, population-based, controlled trial in two regions of Western

SUBMITTER: Nguyen-Soenen J 

PROVIDER: S-EPMC8851828 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature