Reduced learning bias towards the reward context in medication-naive first-episode schizophrenia patients.

ABSTRACT:

Background

Reinforcement learning has been proposed to contribute to the development of amotivation in individuals with schizophrenia (SZ). Accumulating evidence suggests dysfunctional learning in individuals with SZ in Go/NoGo learning and expected value representation. However, previous findings might have been confounded by the effects of antipsychotic exposure. Moreover, reinforcement learning also rely on the learning context. Few studies have examined the learning performance in reward and loss-avoidance context separately in medication-naïve individuals with first-episode SZ. This study aimed to explore the behaviour profile of reinforcement learning performance in medication-naïve individuals with first-episode SZ, including the contextual performance, the Go/NoGo learning

SUBMITTER: Cheng X 

PROVIDER: S-EPMC8851841 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature