Effects of Metformin Combined With Antifolates on HepG2 Cell Metabolism and Cellular Proliferation.

ABSTRACT: Hepatocellular carcinoma (HCC), one of the most prevalent types of cancers worldwide, continues to maintain high levels of resistance to standard therapy. As clinical data revealed poor response rates, the need for developing new methods has increased to improve the overall wellbeing of patients with HCC. Furthermore, a growing body of evidence shows that cancer metabolic changes are a key feature of many types of human malignancies. Metabolic reprogramming refers to cancer cells' ability to change their metabolism in order to meet the increased energy demand caused by continuous growth, rapid proliferation, and other neoplastic cell characteristics. For these reasons, metabolic pathways may become new therapeutic and chemopreventive targets. The aim of this study was to investigate the me

SUBMITTER: Tawfik SM 

PROVIDER: S-EPMC8851913 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature