Proteomic Signatures of Human Visceral and Subcutaneous Adipocytes.

ABSTRACT:

Context

Adipose tissue distribution is a key factor influencing metabolic health and risk in obesity-associated comorbidities.

Objective

Here we aim to compare the proteomic profiles of mature adipocytes from different depots.

Methods

Abdominal subcutaneous (SA) and omental visceral adipocytes (VA) were isolated from paired adipose tissue biopsies obtained during bariatric surgery on 19 severely obese women (body mass index > 30 kg/m2) and analyzed using state-of-the-art mass spectrometry. Differential expression analysis and weighted gene co-expression network analysis (WGCNA) were performed to investigate proteome signature properties and to examine a possible association of the protein expression with the clinical data.

Results

We identified 3686 protein gro

SUBMITTER: Hruska P 

PROVIDER: S-EPMC8851937 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature