Real-World Practice of Hypofractionated Radiotherapy in Patients With Invasive Breast Cancer.

ABSTRACT:

Purpose

Application of hypofractionated radiotherapy (HFRT) is growing in patients with breast cancer (BC). This study aimed to explore a real-world practice of HFRT in early and locally advanced BC.

Methods

Patients with invasive BC between 2015 and 2019 were retrospectively reviewed. Radiotherapy (RT) was delivered by HFRT and conventionally fractionated radiotherapy (CFRT). Locoregional recurrence-free survival (LRRFS) and disease-free survival (DFS) were calculated by Kaplan-Meier curve and compared by Log-rank test. The effect of treatment modality on DFS was estimated by univariate and multivariable analyses.

Results

A total of 1,010 patients were included in this study, and 903 (89.4%) were treated with HFRT. At a median follow-up of 49.5 months, there was no s

SUBMITTER: Chen F 

PROVIDER: S-EPMC8852155 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature