Dichotomy in the Impact of Elevated Maternal Glucose Levels on Neonatal Epigenome.

ABSTRACT:

Context

Antenatal hyperglycemia is associated with increased risk of future adverse health outcomes in both mother and child. Variations in offspring's epigenome can reflect the impact and response to in utero glycemic exposure, and may have different consequences for the child.

Objective

We examined possible differences in associations of basal glucose status and glucose handling during pregnancy with both clinical covariates and offspring cord tissue DNA methylation.

Research design and methods

This study included 830 mother-offspring dyads from the Growing Up in Singapore Towards Healthy Outcomes cohort. The fetal epigenome of umbilical cord tissue was profiled using Illumina HumanMethylation450 arrays. Associations of maternal mid-pregnancy fasting (fasting plasma

SUBMITTER: Lim IY 

PROVIDER: S-EPMC8852163 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature