Development of a core outcome set for multimorbidity trials in low/middle-income countries (COSMOS): study protocol.

ABSTRACT:

Introduction

'Multimorbidity' describes the presence of two or more long-term conditions, which can include communicable, non-communicable diseases, and mental disorders. The rising global burden from multimorbidity is well documented, but trial evidence for effective interventions in low-/middle-income countries (LMICs) is limited. Selection of appropriate outcomes is fundamental to trial design to ensure cross-study comparability, but there is currently no agreement on a core outcome set (COS) to include in trials investigating multimorbidity specifically in LMICs. Our aim is to develop international consensus on two COSs for trials of interventions to prevent and treat multimorbidity in LMIC settings.

Methods and analysis

Following methods recommended by the Core Outcome

SUBMITTER: Boehnke JR 

PROVIDER: S-EPMC8852662 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature