Interaction of diabetes genetic risk and successful lifestyle modification in the Diabetes Prevention Programme.

ABSTRACT:

Aim

To test whether diabetes genetic risk modifies the association of successful lifestyle changes with incident diabetes.

Materials and methods

We studied 823 individuals randomized to the intensive lifestyle intervention (ILS) arm of the Diabetes Prevention Programme who were diabetes-free 1 year after enrolment. We tested additive and multiplicative interactions of a 67-variant diabetes genetic risk score (GRS) with achievement of three ILS goals at 1 year (≥7% weight loss, ≥150 min/wk of moderate leisure-time physical activity, and/or a goal for self-reported total fat intake) on the primary outcome of incident diabetes over 3 years of follow-up.

Results

A lower GRS and achieving each or all three ILS goals were each associated with lower incidence of diabetes (al

SUBMITTER: Raghavan S 

PROVIDER: S-EPMC8852694 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature