Validating risk models versus age alone for atrial fibrillation in a young Dutch population cohort: should atrial fibrillation risk prediction be expanded to younger community members?

ABSTRACT:

Background

Advancing age is the primary selection criterion for community screening for atrial fibrillation (AF), with selection often restricted to those aged ≥65 years. If multivariable models were shown to have considerable additional value over age alone in predicting AF risk among younger individuals, AF screening could be expanded to patients with lower age, but with high AF risk as per a validated risk model.

Methods

We validated risk models CHARGE-AF (Cohorts for Heart and Aging Research in Genomic Epidemiology model for AF) and FHS-AF (Framingham Heart Study model for AF), and risk scores CHA₂DS₂-VASc and CHA₂DS₂-VA, and presented their predictive abilities for 5-year and 10-year AF risk versus that of age alone in a young

SUBMITTER: Himmelreich JCL 

PROVIDER: S-EPMC8852746 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature