KETOgenic diet therapy in patients with HEPatocellular adenoma: study protocol of a matched interventional cohort study.

ABSTRACT:

Introduction

Hepatocellular adenoma (HCA) is an uncommon, solid and benign liver lesion, mainly occurring in women using oral contraceptives. Patients are advised to stop using oral contraceptives (OC) and, as overweight is frequently observed, dietary restrictions. Metabolic changes are assumed to play a role and it has been suggested that diet may help to reduce tumour size. A low-calorie ketogenic diet (LCKD) has been shown to induce weight loss and multiple metabolic changes, including the reduction of portal insulin concentrations, which downregulates hepatic growth hormone receptors. Weight reduction and an LCKD can potentially reduce the size of HCAs.

Methods and analysis

We designed a matched, interventional cohort study to determine the effect of an LCKD on the regr

SUBMITTER: Oudmaijer CAJ 

PROVIDER: S-EPMC8852750 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature