Long-term effects of wildfire smoke exposure during early life on the nasal epigenome in rhesus macaques.

ABSTRACT:

Background

Wildfire smoke is responsible for around 20% of all particulate emissions in the U.S. and affects millions of people worldwide. Children are especially vulnerable, as ambient air pollution exposure during early childhood is associated with reduced lung function. Most studies, however, have focused on the short-term impacts of wildfire smoke exposures. We aimed to identify long-term baseline epigenetic changes associated with early-life exposure to wildfire smoke. We collected nasal epithelium samples for whole genome bisulfite sequencing (WGBS) from two groups of adult female rhesus macaques: one group born just before the 2008 California wildfire season and exposed to wildfire smoke during early-life (n = 8), and the other group born in 2009 with no wildfire smoke expos

SUBMITTER: Brown AP 

PROVIDER: S-EPMC8852822 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature