Alterations of oral microbiota in Chinese children with viral encephalitis and/or viral meningitis.

ABSTRACT: The role of oral microbiota in viral encephalitis and/or viral meningitis (VEVM) remains unclear. In this hospital-based, frequency-matched study, children with clinically diagnosed VEVM (n = 68) and those with other diseases (controls, n = 68) were recruited. Their oral swab samples were collected and the oral microbiota was profiled using 16S rRNA gene sequencing. The oral microbiota of children with VEVM exhibited different beta diversity metrics (unweighted UniFrac distance: P < 0.001, R² = 0.025, Bray-curtis dissimilarity: P = 0.045, R² = 0.011, and Jaccard dissimilarity: P < 0.001, R² = 0.017) and higher relative abundances of taxa identified by Linear discriminant analysis (LDA) with effect size (Enterococcus, Pedobacter, Massilia, Prevotella_9, Psyc

SUBMITTER: Li Y 

PROVIDER: S-EPMC8852926 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature