Pathology findings in pediatric patients with COVID-19 and kidney dysfunction.

ABSTRACT:

Background

Acute kidney injury (AKI) is seen in one-fifth of pediatric patients with COVID-19 requiring hospital admission, and is associated with increased morbidity, mortality, and residual kidney impairment. The majority of kidney pathology data in patients with COVID-19 is derived from adult case series and there is an overall lack of histologic data for most pediatric patients with COVID-19.

Methods

We assembled a multi-institutional cohort of five unvaccinated pediatric patients with COVID-19 and associated kidney dysfunction with available histology.

Results

Three complex patients with current or prior SARS-CoV-2 infection had multifactorial thrombotic microangiopathy with clinical features of hemolytic uremic syndrome (in two) or disseminated intravascular coa

SUBMITTER: Nomura E 

PROVIDER: S-EPMC8853278 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature