Relative changes in brain and kidney biomarkers with Exertional Heat Illness during a cool weather marathon.

ABSTRACT:

Background

Medical personnel may find it challenging to distinguish severe Exertional Heat Illness (EHI), with attendant risks of organ-injury and longer-term sequalae, from lesser forms of incapacity associated with strenuous physical exertion. Early evidence for injury at point-of-incapacity could aid the development and application of targeted interventions to improve outcomes. We aimed to investigate whether biomarker surrogates for end-organ damage sampled at point-of-care (POC) could discriminate EHI versus successful marathon performance.

Methods

Eight runners diagnosed as EHI cases upon reception to medical treatment facilities and 30 successful finishers of the same cool weather marathon (ambient temperature 8 rising to 12 ºC) were recruited. Emerging clinical marke

SUBMITTER: Stacey MJ 

PROVIDER: S-EPMC8853487 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature